Improved Health-Related Quality of Life in Patients with Chronic Lymphocytic Leukemia Treated with Ofatumumab Plus Chlorambucil or Chlorambucil
نویسندگان
چکیده
منابع مشابه
Cost-Effectiveness of Ofatumumab Plus Chlorambucil in First Line Chronic Lymphocytic Leukemia in Canada.
Table 1. Drug Acquisition, Administration, and Monitoring Costs for FirstLine Treatment With OChl and Chl Cost Type OChl Chl Drug acquisition Ofatumumab, 100 mg vial $336 – Chlorambucil, 25 x 2 mg pack $35 $35 Administration Induction infusion in first cycle (O) $1,039 – Regular infusion in subsequent cycles (O) $818 – Oral chemotherapy dispensing (Chl)a $9 $9 Monitoring (per chemo cycle)b $119...
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We present the long-term follow-up and results of subsequent treatments in patients with chronic lymphocytic leukemia treated initially with cladribine + prednisone or chlorambucil + prednisone in a randomized, cross-over study. We found higher complete and overall responses rates in patients who received cladribine + prednisone as first and second-line treatment but no significant differences ...
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Our previous studies with B-cell chronic lymphocytic leukemia (B-CLL) have suggested that one of the mechanisms of nitrogen mustard (NM) drug resistance is increased repair of drug-induced damage. We have postulated that recombination may play a crucial role in this process. The human homologue of Rad51, (HsRad51), has homology to the RecA protein in Escherichia coli, which is implicated in rec...
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Chlorambucil (CLB) uptake by chronic lymphocytic leukemia lymphocytes was studied using a radiometric and a newly developed high-performance liquid chromatography assay. CLB labeled with 14C in either the chloroethyl group or phenyl ring was used with identical results. Drug accumulation by the cells was found to peak at 30 s, was independent of temperature, and was proportional to medium CLB c...
متن کاملHealth-Related Quality of Life and Related Factors in Patients With Chronic Obstructive Pulmonary Disease
Background: Chronic Obstructive Pulmonary Disease (COPD) affects different aspects of patients’ life. By awareness of the quality of life and related factors of each patient, nurses can plan for and do proper care. So the present study was performed to evaluate health-related quality of life and related factors in patients with COPD. Methods: This study is a cross-sectional descriptive r...
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ژورنال
عنوان ژورنال: Value in Health
سال: 2014
ISSN: 1098-3015
DOI: 10.1016/j.jval.2014.03.551